Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux

We and others have recently shown that loss of the mitochondrial membrane potential (Δψ) precedes apoptosis and chemical-hypoxia-induced necrosis and is prevented by Bcl-2. In this report, we examine the biochemical mechanism used by Bcl-2 to prevent Δψ loss, as determined with mitochondria isolated...

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הוצא לאור ב:	Proc Natl Acad Sci U S A
Principais autores:	Shimizu, Shigeomi, Eguchi, Yutaka, Kamiike, Wataru, Funahashi, Yoshimitsu, Mignon, Alexandre, Lacronique, Virginia, Matsuda, Hikaru, Tsujimoto, Yoshihide
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	National Academy of Sciences 1998
נושאים:	Biological Sciences
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19042/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9465036/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.4.1455
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