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The stochastic behavior of a molecular switching circuit with feedback

BACKGROUND: Using a statistical physics approach, we study the stochastic switching behavior of a model circuit of multisite phosphorylation and dephosphorylation with feedback. The circuit consists of a kinase and phosphatase acting on multiple sites of a substrate that, contingent on its modificat...

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Detalles Bibliográficos
Autores principales: Krishnamurthy, Supriya, Smith, Eric, Krakauer, David, Fontana, Walter
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904185/
https://ncbi.nlm.nih.gov/pubmed/17540019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-6150-2-13
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