Inhibition of human immunodeficiency virus type 1 integrase by the Fab fragment of a specific monoclonal antibody suggests that different multimerization states are required for different enzymatic functions.

We have characterized a murine monoclonal antibody (MAb 35), which was raised against human immunodeficiency virus type 1 (HIV-1) integration protein (IN), and the corresponding Fab 35. Although MAb 35 does not inhibit HIV-1 IN, Fab 35 does. MAb 35 (and Fab 35) binds to an epitope in the C-terminal...

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Detalles Bibliográficos

Publicado en:	J Virol
Principais autores:	Barsov, E V, Huber, W E, Marcotrigiano, J, Clark, P K, Clark, A D, Arnold, E, Hughes, S H
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190383/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8676473/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.7.4484-4494.1996
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