Genetic analysis of polyomavirus large T nuclear localization: nuclear localization is required for productive association with pRb family members.

Polyomavirus large T antigen (LT) is a multifunctional nuclear protein. LT has two nuclear localization signals (NLS2), one spanning residues 189 to 195 (NLS1) and another spanning residues 280 to 286 (NLS2). Site-directed mutagenesis showed that each signal contains at least two critical residues....

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Howes, S H, Bockus, B J, Schaffhausen, B S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190233/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8648692/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.6.3581-3588.1996
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