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An N-terminal deletion mutant of simian virus 40 (SV40) large T antigen oligomerizes incorrectly on SV40 DNA but retains the ability to bind to DNA polymerase alpha and replicate SV40 DNA in vitro.

A peptide encompassing the N-terminal 82 amino acids of simian virus 40 (SV40) large T antigen was previously shown to bind to the large subunit of DNA polymerase alpha-primase (I. Dornreiter, A. Höss, A. K. Arthur, and E. Fanning, EMBO J. 9:3329-3336, 1990). We report here that a mutant T antigen,...

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Gardado en:
Publicado en:J Virol
Principais autores: Weisshart, K, Bradley, M K, Weiner, B M, Schneider, C, Moarefi, I, Fanning, E, Arthur, A K
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 1996
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190225/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8648684/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.6.3509-3516.1996
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