Cross-Clade Inhibition of Recombinant Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus SIVcpz Reverse Transcriptases by RNA Pseudoknot Aptamers

Reverse transcriptase (RT) remains a primary target in therapies directed at human immunodeficiency virus type 1 (HIV-1). RNA aptamers that bind RT from HIV-1 subtype B have been shown to protect human cells from infection and to reduce viral infectivity, but little is known about the sensitivity of...

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Autors principals: Held, Daniel M., Kissel, Jay D., Thacker, Sarah J., Michalowski, Daniel, Saran, Dayal, Ji, Jianfei, Hardy, Richard W., Rossi, John J., Burke, Donald H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2007
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900219/
https://ncbi.nlm.nih.gov/pubmed/17329328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01923-06
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