Adenovirus-Platelet Interaction in Blood Causes Virus Sequestration to the Reticuloendothelial System of the Liver

Intravenous (i.v.) delivery of recombinant adenovirus serotype 5 (Ad5) vectors for gene therapy is hindered by safety and efficacy problems. We have discovered a new pathway involved in unspecific Ad5 sequestration and degradation. After i.v. administration, Ad5 rapidly binds to circulating platelet...

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Bibliographic Details
Main Authors: Stone, Daniel, Liu, Ying, Shayakhmetov, Dmitry, Li, Zong-Yi, Ni, Shaoheng, Lieber, André
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2007
Subjects:
Gene Delivery
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900148/
https://ncbi.nlm.nih.gov/pubmed/17301138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02819-06
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