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Control of CNS Cell Fate Decisions by SHP-2 and its Dysregulation in Noonan Syndrome
Within the developing mammalian CNS, growth factors direct multipotent precursors to generate neurons versus glia, a process that if perturbed might lead to neural dysfunction. In this regard, genetic mutations resulting in constitutive activation of the protein tyrosine phosphatase SHP-2 cause Noon...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1900070/ https://ncbi.nlm.nih.gov/pubmed/17442246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2007.03.027 |
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