Control of CNS Cell Fate Decisions by SHP-2 and its Dysregulation in Noonan Syndrome

Within the developing mammalian CNS, growth factors direct multipotent precursors to generate neurons versus glia, a process that if perturbed might lead to neural dysfunction. In this regard, genetic mutations resulting in constitutive activation of the protein tyrosine phosphatase SHP-2 cause Noon...

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Bibliografiske detaljer
Main Authors: Gauthier, Andrée S., Furstoss, Olivia, Araki, Toshiyuki, Chan, Richard, Neel, Benjamin G., Kaplan, David R., Miller, Freda D.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900070/
https://ncbi.nlm.nih.gov/pubmed/17442246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2007.03.027
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