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DNA Repair and Transcriptional Deficiencies Caused by Mutations in the Drosophila p52 Subunit of TFIIH Generate Developmental Defects and Chromosome Fragility

The transcription and DNA repair factor TFIIH is composed of 10 subunits. Mutations in the XPB, XPD, and p8 subunits are genetically linked to human diseases, including cancer. However, no reports of mutations in other TFIIH subunits have been reported in higher eukaryotes. Here, we analyze at genet...

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Bibliografski detalji
Glavni autori: Fregoso, Mariana, Lainé, Jean-Philippe, Aguilar-Fuentes, Javier, Mocquet, Vincent, Reynaud, Enrique, Coin, Frédéric, Egly, Jean-Marc, Zurita, Mario
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2007
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899989/
https://ncbi.nlm.nih.gov/pubmed/17339330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00030-07
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