p8/TTDA Overexpression Enhances UV-Irradiation Resistance and Suppresses TFIIH Mutations in a Drosophila Trichothiodystrophy Model

Mutations in certain subunits of the DNA repair/transcription factor complex TFIIH are linked to the human syndromes xeroderma pigmentosum (XP), Cockayne's syndrome (CS), and trichothiodystrophy (TTD). One of these subunits, p8/TTDA, interacts with p52 and XPD and is important in maintaining TF...

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Bibliographic Details
Main Authors: Aguilar-Fuentes, Javier, Fregoso, Mariana, Herrera, Mariana, Reynaud, Enrique, Braun, Cathy, Egly, Jean Marc, Zurita, Mario
Format: Artigo
Language:Inglês
Published: Public Library of Science 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576456/
https://ncbi.nlm.nih.gov/pubmed/19008953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000253
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