TFIIH-dependent MMP-1 overexpression in trichothiodystrophy leads to extracellular matrix alterations in patient skin

Mutations in the XPD subunit of the DNA repair/transcription factor TFIIH result in distinct clinical entities, including the cancer-prone xeroderma pigmentosum (XP) and the multisystem disorder trichothiodystrophy (TTD), which share only cutaneous photosensitivity. Gene-expression profiles of prima...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Arseni, Lavinia, Lanzafame, Manuela, Compe, Emmanuel, Fortugno, Paola, Afonso-Barroso, António, Peverali, Fiorenzo A., Lehmann, Alan R., Zambruno, Giovanna, Egly, Jean-Marc, Stefanini, Miria, Orioli, Donata
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2015
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321311/
https://ncbi.nlm.nih.gov/pubmed/25605938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416181112
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