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DNA Repair and Transcriptional Deficiencies Caused by Mutations in the Drosophila p52 Subunit of TFIIH Generate Developmental Defects and Chromosome Fragility

The transcription and DNA repair factor TFIIH is composed of 10 subunits. Mutations in the XPB, XPD, and p8 subunits are genetically linked to human diseases, including cancer. However, no reports of mutations in other TFIIH subunits have been reported in higher eukaryotes. Here, we analyze at genet...

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Bibliografiske detaljer
Main Authors: Fregoso, Mariana, Lainé, Jean-Philippe, Aguilar-Fuentes, Javier, Mocquet, Vincent, Reynaud, Enrique, Coin, Frédéric, Egly, Jean-Marc, Zurita, Mario
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899989/
https://ncbi.nlm.nih.gov/pubmed/17339330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00030-07
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