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Efficient initiation and strand transfer of polypurine tract-primed plus-strand DNA prevent strand transfer of internally initiated plus-strand DNA.

A critical step in retroviral reverse transcription is the initiation of plus-strand DNA synthesis at the polypurine tract (PPT) and strand transfer of the PPT-primed strong-stop DNA to the 5' end of the viral DNA. An attachment site (att) immediately 3' to the PPT is essential for proper integratio...

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Published in:J Virol
Main Authors: Bowman, E H, Pathak, V K, Hu, W S
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1996
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189992/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8627689/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.3.1687-1694.1996
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