Impact of the Central Polypurine Tract on the Kinetics of Human Immunodeficiency Virus Type 1 Vector Transduction

Lentiviral vectors derived from human immunodeficiency virus type 1 (HIV-1) show great promise as gene carriers for future gene therapy. Insertion of a fragment containing the central polypurine tract (cPPT) in HIV-1 vector constructs is known to enhance transduction efficiency drastically, reported...

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Autores principales: Van Maele, Bénédicte, De Rijck, Jan, De Clercq, Erik, Debyser, Zeger
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
Gene Therapy
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC152151/
https://ncbi.nlm.nih.gov/pubmed/12663775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.8.4685-4694.2003
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