Inverted DNA Repeats Channel Repair of Distant Double-Strand Breaks into Chromatid Fusions and Chromosomal Rearrangements

Inverted DNA repeats are known to cause genomic instabilities. Here we demonstrate that double-strand DNA breaks (DSBs) introduced a large distance from inverted repeats in the yeast (Saccharomyces cerevisiae) chromosome lead to a burst of genomic instability. Inverted repeats located as far as 21 k...

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Main Authors: VanHulle, Kelly, Lemoine, Francene J., Narayanan, Vidhya, Downing, Brandon, Hull, Krista, McCullough, Christy, Bellinger, Melissa, Lobachev, Kirill, Petes, Thomas D., Malkova, Anna
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2007
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899885/
https://ncbi.nlm.nih.gov/pubmed/17242181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01740-06
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