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Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS.

Three human cytomegalovirus (HCMV) strains (VR4760, VR4955, and VR5120) showing double resistance to ganciclovir (GCV) and foscarnet (PFA) were isolated from three patients with AIDS who underwent multiple sequential courses of therapy with GCV and PFA (A. Sarasini, F. Baldanti, M. Furione, E. Perci...

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Published in:J Virol
Main Authors: Baldanti, F, Underwood, M R, Stanat, S C, Biron, K K, Chou, S, Sarasini, A, Silini, E, Gerna, G
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1996
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189958/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8627655/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.3.1390-1395.1996
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