Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS.

Three human cytomegalovirus (HCMV) strains (VR4760, VR4955, and VR5120) showing double resistance to ganciclovir (GCV) and foscarnet (PFA) were isolated from three patients with AIDS who underwent multiple sequential courses of therapy with GCV and PFA (A. Sarasini, F. Baldanti, M. Furione, E. Perci...

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izdano v:	J Virol
Principais autores:	Baldanti, F, Underwood, M R, Stanat, S C, Biron, K K, Chou, S, Sarasini, A, Silini, E, Gerna, G
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 1996
Teme:	Research Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189958/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8627655/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.3.1390-1395.1996
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