Immune system-dependent and -independent replication of the scrapie agent.

Using the severe combined immunodeficiency (SCID) mouse model, we investigated the requirement of the immune system for the development of scrapie after peripheral inoculation. A total of 33% of SCID mice, all but one immunologically reconstituted SCID mice (93%), and all CB17 control mice developed...

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Autors principals: Lasmézas, C I, Cesbron, J Y, Deslys, J P, Demaimay, R, Adjou, K T, Rioux, R, Lemaire, C, Locht, C, Dormont, D
Format: Artigo
Idioma:Inglês
Publicat: 1996
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC189946/
https://ncbi.nlm.nih.gov/pubmed/8551598
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