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Opposite Effects of Dextran Sulfate 500, the Polyene Antibiotic MS-8209, and Congo Red on Accumulation of the Protease-Resistant Isoform of PrP in the Spleens of Mice Inoculated Intraperitoneally with the Scrapie Agent

The mode and the site of action of the major antiscrapie drugs have been studied by investigating their effects on the abnormal protease-resistant isoform of PrP (PrPres) and on its accumulation in mouse spleen. Day-by-day PrPres accumulation in the spleen and in other peripheral organs was first mo...

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Udgivet i:J Virol
Principais autores: Beringue, Vincent, Adjou, Karim T., Lamoury, François, Maignien, Thomas, Deslys, Jean-Philippe, Race, Richard, Dormont, Dominique
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2000
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112027/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10823847/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.12.5432-5440.2000
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