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Endothelin-1 Induces Alveolar Epithelial–Mesenchymal Transition through Endothelin Type A Receptor–Mediated Production of TGF-β1

Endothelin-1 (ET-1) is implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF), but the cellular mechanisms underlying the role it plays in this disease are not well characterized. Epithelial–mesenchymal transition (EMT), which was recently demonstrated in alveolar epithelial cells (AE...

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Bibliografiske detaljer
Main Authors: Jain, Raksha, Shaul, Philip W., Borok, Zea, Willis, Brigham C.
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899351/
https://ncbi.nlm.nih.gov/pubmed/17379848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2006-0353OC
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