Induction of Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells by Transforming Growth Factor-β1 : Potential Role in Idiopathic Pulmonary Fibrosis

The hallmark of idiopathic pulmonary fibrosis (IPF) is the myofibroblast, the cellular origin of which in the lung is unknown. We hypothesized that alveolar epithelial cells (AECs) may serve as a source of myofibroblasts through epithelial-mesenchymal transition (EMT). Effects of chronic exposure to...

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Autors principals: Willis, Brigham C., Liebler, Janice M., Luby-Phelps, Katherine, Nicholson, Andrew G., Crandall, Edward D., du Bois, Roland M., Borok, Zea
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2005
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Original Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1606388/
https://ncbi.nlm.nih.gov/pubmed/15855634
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