Caspase-3 Regulation of Diaphragm Myonuclear Domain during Mechanical Ventilation–induced Atrophy

Rationale: Unloading the diaphragm via mechanical ventilation (MV) results in rapid diaphragmatic fiber atrophy. It is unknown whether the myonuclear domain (cytoplasmic myofiber volume/myonucleus) of diaphragm myofibers is altered during MV. Objective: We tested the hypothesis that MV-induced diaph...

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Detalhes bibliográficos
Main Authors: McClung, Joseph M., Kavazis, Andreas N., DeRuisseau, Keith C., Falk, Darin J., Deering, Melissa A., Lee, Youngil, Sugiura, Takao, Powers, Scott K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2007
Assuntos:
C. Critical Care
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899279/
https://ncbi.nlm.nih.gov/pubmed/17082496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200601-142OC
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