Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB–Akt) signalling

Oxidative stress promotes controlled mechanical ventilation (MV)-induced diaphragmatic atrophy. Nonetheless, the signalling pathways responsible for oxidative stress-induced muscle atrophy remain unknown. We tested the hypothesis that oxidative stress down-regulates insulin-like growth factor-1–phos...

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Detalhes bibliográficos
Main Authors: McClung, J M, Kavazis, A N, Whidden, M A, DeRuisseau, K C, Falk, D J, Criswell, D S, Powers, S K
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2007
Assuntos:
Respiratory
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375462/
https://ncbi.nlm.nih.gov/pubmed/17916612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.141119
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