CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge.

Although primary antiviral CD8+ cytotoxic T lymphocytes (CTL) can be induced in mice depleted of CD4+ T cells, the role of CD4+ T lymphocytes in the generation and maintenance of antiviral memory CTL is uncertain. This question, and the consequences upon vaccine-mediated protection, were investigate...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	von Herrath, M G, Yokoyama, M, Dockter, J, Oldstone, M B, Whitton, J L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189913/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8551565/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.2.1072-1079.1996
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