Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis.

Adeno-associated virus is an integrating DNA parvovirus with the potential to be an important vehicle for somatic gene therapy. A potential barrier, however, is the low transduction efficiencies of recombinant adeno-associated virus (rAAV) vectors. We show in this report that adenovirus dramatically...

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Pubblicato in:	J Virol
Autori principali:	Fisher, K J, Gao, G P, Weitzman, M D, DeMatteo, R, Burda, J F, Wilson, J M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189840/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8523565/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.1.520-532.1996
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