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Altered gating of opiate receptor-modulated K(+) channels on amygdala neurons of morphine-dependent rats

The molecular mechanism of tolerance to opiate drugs is poorly understood. We have used single-channel patch–clamp recordings to study opiate receptor effects on dissociated neurons from rat amygdala, a limbic region implicated in addiction processes. A 130-pS inwardly rectifying K(+)-preferring cat...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Chen, Xueguang, Marrero, Hector G., Murphy, Ricardo, Lin, Yong-Jian, Freedman, Jonathan E.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18980/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11121070/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.26.14692
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