Induction of susceptibility to tumor necrosis factor by E1A is dependent on binding to either p300 or p105-Rb and induction of DNA synthesis.

The introduction of the adenovirus early region 1A (E1A) gene products into normal cells sensitizes these cells to the cytotoxic effects of tumor necrosis factor (TNF). Previous studies have shown that the region of E1A responsible for susceptibility is CR1, a conserved region within E1A which binds...

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Pubblicato in:	J Virol
Autori principali:	Shisler, J, Duerksen-Hughes, P, Hermiston, T M, Wold, W S, Gooding, L R
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189789/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8523594/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.1.68-77.1996
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