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The coxsackievirus A9 RGD motif is not essential for virus viability.

An RGD (arginine-glycine-aspartic acid) motif in coxsackievirus A9 has been implicated in internalization through an interaction with the integrin alpha v beta 3. We have produced a number of virus mutants, lacking the motif, which have a small-plaque phenotype in LLC-Mk2 and A-Vero cells and are ph...

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Detalhes bibliográficos
Publicado no:J Virol
Principais autores: Hughes, P J, Horsnell, C, Hyypiä, T, Stanway, G
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1995
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189749/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7494317/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.69.12.8035-8040.1995
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