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Cleavage of VP1 and modification of antigenic site 1 of type 2 polioviruses by intestinal trypsin.

We have exposed 22 independent type 2 poliovirus isolates to human intestinal fluid and purified trypsin. In all cases the virus retained its infectivity, while polyacrylamide gel electrophoresis of viral proteins showed disappearance of the VP1 bands. Concomitantly, the viruses became resistant to...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Roivainen, M, Hovi, T
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 1988
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC253485/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2841503/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.62.9.3536-3539.1988
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