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The human hematopoietic stem cell compartment is heterogeneous for CXCR4 expression

The chemokine stromal derived factor-1α (SDF-1α) has been implicated recently in the chemotaxis of primitive human hematopoietic cells, suggesting that pluripotent human stem cells express the SDF-1α receptor, CXCR4. By using flow cytometry and confocal microscopy, we have identified and isolated pr...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Rosu-Myles, Michael, Gallacher, Lisa, Murdoch, Barbara, Hess, David A., Keeney, Mike, Kelvin, David, Dale, Leanne, Ferguson, Stephen S. G., Wu, Dongmei, Fellows, Fraser, Bhatia, Mickie
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2000
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18969/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11121064/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.26.14626
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