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C-Metalated Nitriles: Electrophile-Dependent Alkylations and Acylations

Sequential carbonyl addition-conjugate addition of Grignard reagents to 3-oxocyclohex-1-ene-1-carbonitrile generates C-magnesiated nitriles whose alkylation stereoselectivities intimately depend on the nature of the electrophile. Alkylating these C-magnesiated nitriles with alkyl halides, sulfonates...

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Bibliografiska uppgifter
Huvudupphovsmän: Fleming, Fraser F., Zhang, Zhiyu, Wei, Guoqing, Steward, Omar W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2006
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1896272/
https://ncbi.nlm.nih.gov/pubmed/16468790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo052102j
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