CAG-encoded polyglutamine length polymorphism in the human genome

BACKGROUND: Expansion of polyglutamine-encoding CAG trinucleotide repeats has been identified as the pathogenic mutation in nine different genes associated with neurodegenerative disorders. The majority of individuals clinically diagnosed with spinocerebellar ataxia do not have mutations within know...

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Autori principali: Butland, Stefanie L, Devon, Rebecca S, Huang, Yong, Mead, Carri-Lyn, Meynert, Alison M, Neal, Scott J, Lee, Soo Sen, Wilkinson, Anna, Yang, George S, Yuen, Macaire MS, Hayden, Michael R, Holt, Robert A, Leavitt, Blair R, Ouellette, BF Francis
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2007
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1896166/
https://ncbi.nlm.nih.gov/pubmed/17519034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-8-126
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