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NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells

The proteasome has been successfully targeted for the treatment of multiple myeloma and mantle cell lymphoma; however, in other hematologic malignancies, bortezomib has been less effective as a single agent. Here, we describe effects of NPI-0052, a novel proteasome inhibitor, in leukemia model syste...

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Autors principals: Miller, Claudia P., Ban, Kechen, Dujka, Melanie E., McConkey, David J., Munsell, Mark, Palladino, Michael, Chandra, Joya
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1896116/
https://ncbi.nlm.nih.gov/pubmed/17356134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-03-013128
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