Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: a mechanism for synergy in leukemia cells

Combination studies of histone deacetylase inhibitors (HDACi) and proteasome inhibitors are providing preclinical framework to build better strategies against hematologic malignancies. Our previous work found that a novel proteasome inhibitor, NPI-0052, and HDACi synergistically induce apoptosis in...

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Bibliographic Details
Main Authors: Miller, Claudia P., Rudra, Sharmistha, Keating, Michael J., Wierda, William G., Palladino, Michael, Chandra, Joya
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2009
Subjects:
Lymphoid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676087/
https://ncbi.nlm.nih.gov/pubmed/19182209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-08-174797
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