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Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: a mechanism for synergy in leukemia cells

Combination studies of histone deacetylase inhibitors (HDACi) and proteasome inhibitors are providing preclinical framework to build better strategies against hematologic malignancies. Our previous work found that a novel proteasome inhibitor, NPI-0052, and HDACi synergistically induce apoptosis in...

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Detalhes bibliográficos
Main Authors: Miller, Claudia P., Rudra, Sharmistha, Keating, Michael J., Wierda, William G., Palladino, Michael, Chandra, Joya
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676087/
https://ncbi.nlm.nih.gov/pubmed/19182209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-08-174797
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