HIV-1 escape from the entry-inhibiting effects of a cholesterol-binding compound via cleavage of gp41 by the viral protease

HIV-1 virions are highly enriched in cholesterol relative to the cellular plasma membrane. We recently reported that a cholesterol-binding compound, amphotericin B methyl ester (AME), blocks HIV-1 entry and that single amino acid substitutions in the cytoplasmic tail of the transmembrane envelope gl...

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Detalles Bibliográficos
Autores principales: Waheed, Abdul A., Ablan, Sherimay D., Roser, James D., Sowder, Raymond C., Schaffner, Carl P., Chertova, Elena, Freed, Eric O.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2007
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895973/
https://ncbi.nlm.nih.gov/pubmed/17483482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701443104
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