Effect of Mutations in the Human Immunodeficiency Virus Type 1 Protease on Cleavage of the gp41 Cytoplasmic Tail

We previously reported that human immunodeficiency virus type 1 (HIV-1) develops resistance to the cholesterol-binding compound amphotericin B methyl ester (AME) by acquiring mutations (P203L and S205L) in the cytoplasmic tail of the transmembrane envelope glycoprotein gp41 that create cleavage site...

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Detalhes bibliográficos
Main Authors: Waheed, Abdul A., Ablan, Sherimay D., Sowder, Raymond C., Roser, James D., Schaffner, Carl P., Chertova, Elena, Freed, Eric O.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826043/
https://ncbi.nlm.nih.gov/pubmed/20042499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02002-09
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