Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium

Proteins are involved in various equilibria that play a major role in their activity or regulation. The design of molecules that shift such equilibria is of great therapeutic potential. This fact was demonstrated in the cases of allosteric inhibitors, which shift the equilibrium between active and i...

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Detalles Bibliográficos
Autores principales: Hayouka, Zvi, Rosenbluh, Joseph, Levin, Aviad, Loya, Shoshana, Lebendiker, Mario, Veprintsev, Dmitry, Kotler, Moshe, Hizi, Amnon, Loyter, Abraham, Friedler, Assaf
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2007
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895947/
https://ncbi.nlm.nih.gov/pubmed/17488811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700781104
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