Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium

Proteins are involved in various equilibria that play a major role in their activity or regulation. The design of molecules that shift such equilibria is of great therapeutic potential. This fact was demonstrated in the cases of allosteric inhibitors, which shift the equilibrium between active and i...

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Autori principali: Hayouka, Zvi, Rosenbluh, Joseph, Levin, Aviad, Loya, Shoshana, Lebendiker, Mario, Veprintsev, Dmitry, Kotler, Moshe, Hizi, Amnon, Loyter, Abraham, Friedler, Assaf
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2007
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895947/
https://ncbi.nlm.nih.gov/pubmed/17488811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700781104
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