Loss of Tie2 receptor compromises embryonic stem cell–derived endothelial but not hematopoietic cell survival

Tie2 is a receptor-type tyrosine kinase expressed on hematopoietic stem cells and endothelial cells. We used cultured embryonic stem (ES) cells to determine the function of Tie2 during early vascular development and hematopoiesis. Upon differentiation, the ES cell–derived Tie2(+)Flk1(+) fraction was...

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Autores principales: Hamaguchi, Isao, Morisada, Tohru, Azuma, Masaki, Murakami, Kyoko, Kuramitsu, Madoka, Mizukami, Takuo, Ohbo, Kazuyuki, Yamaguchi, Kazunari, Oike, Yuichi, Dumont, Daniel J., Suda, Toshio
Formato: Artigo
Lenguaje:Inglês
Publicado: © 2006 by The American Society of Hematology 2006
Materias:
Stem Cells in Hematology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895914/
https://ncbi.nlm.nih.gov/pubmed/16219799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-05-1823
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