Loss of Tie2 receptor compromises embryonic stem cell–derived endothelial but not hematopoietic cell survival

Tie2 is a receptor-type tyrosine kinase expressed on hematopoietic stem cells and endothelial cells. We used cultured embryonic stem (ES) cells to determine the function of Tie2 during early vascular development and hematopoiesis. Upon differentiation, the ES cell–derived Tie2(+)Flk1(+) fraction was...

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Bibliografiska uppgifter
Huvudupphovsmän: Hamaguchi, Isao, Morisada, Tohru, Azuma, Masaki, Murakami, Kyoko, Kuramitsu, Madoka, Mizukami, Takuo, Ohbo, Kazuyuki, Yamaguchi, Kazunari, Oike, Yuichi, Dumont, Daniel J., Suda, Toshio
Materialtyp: Artigo
Språk:Inglês
Publicerad: © 2006 by The American Society of Hematology 2006
Ämnen:
Stem Cells in Hematology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895914/
https://ncbi.nlm.nih.gov/pubmed/16219799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-05-1823
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