EFA (9-β-D-erythrofuranosyladenine) is an effective salvage agent for methylthioadenosine phosphorylase-selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine

The deficiency of methylthioadenosine phosphorylase (MTAP) in T-cell acute lymphoblastic leukemia (T-ALL) and other cancers, while constitutively expressed in normal cells, allows for selective therapy using L-alanosine, an inhibitor of de novo AMP synthesis. We demonstrate that MTAP(-) T-ALL cells...

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Detalhes bibliográficos
Main Authors: Batova, Ayse, Cottam, Howard, Yu, John, Diccianni, Mitchell B., Carrera, Carlos J., Yu, Alice L.
Formato: Artigo
Idioma:Inglês
Publicado em: © 2006 by The American Society of Hematology 2006
Assuntos:
Clinical Trials and Observations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895892/
https://ncbi.nlm.nih.gov/pubmed/16234352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-06-2430
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