Flanking HS-62.5 and 3′ HS1, and regions upstream of the LCR, are not required for β-globin transcription

The locus control region (LCR) was thought to be necessary and sufficient for establishing and maintaining an open β-globin locus chromatin domain in the repressive environment of the developing erythrocyte. However, deletion of the LCR from the endogenous locus had no significant effect on chromati...

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Autores principales: Bender, M. A., Byron, Rachel, Ragoczy, Tobias, Telling, Agnes, Bulger, Michael, Groudine, Mark
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society of Hematology 2006
Materias:
Red Cells
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895883/
https://ncbi.nlm.nih.gov/pubmed/16645164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-04-014431
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