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Flanking HS-62.5 and 3′ HS1, and regions upstream of the LCR, are not required for β-globin transcription
The locus control region (LCR) was thought to be necessary and sufficient for establishing and maintaining an open β-globin locus chromatin domain in the repressive environment of the developing erythrocyte. However, deletion of the LCR from the endogenous locus had no significant effect on chromati...
Tallennettuna:
| Päätekijät: | , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
The American Society of Hematology
2006
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1895883/ https://ncbi.nlm.nih.gov/pubmed/16645164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-04-014431 |
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