H3 K79 dimethylation marks developmental activation of the β-globin gene but is reduced upon LCR-mediated high-level transcription

Genome-wide analyses of the relationship between H3 K79 dimethylation and transcription have revealed contradictory results. To clarify this relationship at a single locus, we analyzed expression and H3 K79 modification levels of wild-type (WT) and transcriptionally impaired β-globin mutant genes du...

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Detalhes bibliográficos
Main Authors: Sawado, Tomoyuki, Halow, Jessica, Im, Hogune, Ragoczy, Tobias, Bresnick, Emery H., Bender, M. A., Groudine, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Red Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442750/
https://ncbi.nlm.nih.gov/pubmed/18441235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-12-128983
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