Abnormal disulfide-linked oligomerization results in ER retention and altered signaling by TNFR1 mutants in TNFR1-associated periodic fever syndrome (TRAPS)

Tumor necrosis factor (TNF) receptor–associated periodic syndrome (TRAPS) is an autosomal dominant systemic autoinflammatory disease associated with heterozygous mutations in TNF receptor 1 (TNFR1). Here we examined the structural and functional alterations caused by 9 distinct TRAPS-associated TNFR...

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Bibliografiset tiedot
Päätekijät: Lobito, Adrian A., Kimberley, Fiona C., Muppidi, Jagan R., Komarow, Hirsh, Jackson, Adrianna J., Hull, Keith M., Kastner, Daniel L., Screaton, Gavin R., Siegel, Richard M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The American Society of Hematology 2006
Aiheet:
Immunobiology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895878/
https://ncbi.nlm.nih.gov/pubmed/16684962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-11-006783
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