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Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells
Newborns are prone to microbial infection and have poor memory responses to multiple antigens. We have previously shown that human neonatal blood monocytes exhibit impaired TNF-α responses to most known TLR agonists, including the pure TLR7 agonist imiquimod. Surprisingly, however, neonatal TNF-α re...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society of Hematology
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1895876/ https://ncbi.nlm.nih.gov/pubmed/16638933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-12-4821 |
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