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Autoreactive MZ and B-1 B-cell activation by Fas(lpr) is coincident with an increased frequency of apoptotic lymphocytes and a defect in macrophage clearance

Murine autoreactive anti-Smith (Sm) B cells are negatively regulated by anergy and developmental arrest, but are also positively selected into the marginal zone (MZ) and B-1 B-cell populations. Despite positive selection, anti-Sm production occurs only in autoimmune-prone mice. To investigate autore...

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Detalhes bibliográficos
Main Authors: Qian, Ye, Conway, Kara L., Lu, Xiangdong, Seitz, Heather M., Matsushima, Glenn K., Clarke, Stephen H.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895857/
https://ncbi.nlm.nih.gov/pubmed/16861350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-12-006858
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