Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling

Overexpression of intracellular Notch plays an important role in the generation of human acute lymphoblastic T cell leukemia (T-ALL). In mouse models, it was shown that Notch-dependent T-ALL required pre-TCR signaling. Here we show that pre-TCR signaling is required to condition mice for Notch-depen...

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Bibliografiske detaljer
Main Authors: Campese, Antonio F., Garbe, Annette I., Zhang, Fangrong, Grassi, Fabio, Screpanti, Isabella, von Boehmer, Harald
Format: Artigo
Sprog:Inglês
Udgivet: The American Society of Hematology 2006
Fag:
Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895839/
https://ncbi.nlm.nih.gov/pubmed/16507772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-01-0143
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